منابع مشابه
Improved Statistical Translation Through Editing
In this paper we introduce Linear B's statistical machine translation system. We describe how Linear B's phrase-based translation models are learned from a parallel corpus, and show how the quality of the translations produced by our system can be improved over time through editing. There are two levels at which our translations can be edited. The first is through a simple correction of the tex...
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The NP-hard Bicluster Editing is to add or remove at most k edges to make a bipartite graph G = (V,E) a vertex-disjoint union of complete bipartite subgraphs. It has applications in the analysis of gene expression data. We show that by polynomial-time preprocessing, one can shrink a problem instance to one with 4k vertices, thus proving that the problem has a linear kernel, improving a quadrati...
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Kok et al. conclude that results with Morpholino oligos, which are not recapitulated by natural mutations or gene editing mutations, must be due to off-target effects and, when morphants and mutants differ, they contend that antisense oligo studies should be disregarded. Morpholinos and gene editing mutagenesis are very different technologies and, even if both work perfectly, may yield differen...
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CRISPR/Cas9 is a rapidly developing genome editing technology that has been successfully applied in many organisms, including model and crop plants. Cas9, an RNA-guided DNA endonuclease, can be targeted to specific genomic sequences by engineering a separately encoded guide RNA with which it forms a complex. As only a short RNA sequence must be synthesized to confer recognition of a new target,...
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Editing in plant mitochondria consists in C to U changes and mainly affects messenger RNAs, thus providing the correct genetic information for the biosynthesis of mitochondrial (mt) proteins. But editing can also affect some of the plant mt tRNAs encoded by the mt genome. In dicots, a C to U editing event corrects a C:A mismatch into a U:A base-pair in the acceptor stem of mt tRNAPhe (GAA). In ...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2019
ISSN: 1471-0072,1471-0080
DOI: 10.1038/s41580-019-0207-2